BIOC3053
(BL38B) – CELL SIGNALLING
Intracellular
Signalling (3)
Polarity
- unequal cell division and differentiation.
Selected examples including Acetabularia
& Fucoid eggs. Electrical
fields and calcium. [1-3]
Intercellular
Signalling (23)
Hormones
(3)
The
classical hormone concept – hormone, receptor, effector.
Sexual pheromones in @lower@
organisms. Cell signalling between
unicells and the evolution of hormones. Molecular
approaches to studying hormone action [4-6].
Animal
hormones (8)
Major
categories of animal hormones and physiological effects.
Peptides & catecholamines - 2nd messenger concept, cAMP and
G-proteins, protein phosphorylation, GPCRs. Other G-protein based systems.
The PI cycle and other effectors. Steroid
hormone action - classes of steroid hormones, historical background including
puff induction and the 2 step model. Steroid receptors as gene regulatory
proteins. Gene activation.
[7-14]
Plant
hormones (12)
Do
plants have hormones? Auxin and
ethylene as inducers of wall “loosening”. Auxin biosynthesis and transport.
Auxin binding protein and signal transduction - gene activation, proton pump
hypothesis. Biochemistry of the dicot cell wall. Mechanisms for auxin-induced
wall loosening. C2H4 biosynthesis and its modification by
genetic engineering. The C2H4 receptor, 2-component signal
transducers & C2H4-signal transduction.
Ripening-related wall loosening & its manipulation [15‑26]
2004-01-14
CMSC